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Morbidity Mortality Weekly Reports Selection (re HDCN)


Relevant FDA actions

The U.S. Food and Drug Administration (FDA) home page address is http://www.fda.gov. --(FDA News) --(MedWatch)

FDA strengthening warning label for propulsid (cisapride) (Jun 1998 FDA)
* Roche Laboratories recalls Posicor (mibefradil) (June 8, 1998). See also:  Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers (Jul 98 JAMA)
* Bradycardia and rhabdomyolysis with mibefradil (February 4, 1998)
* FDA announces withdrawal of fenfluramine and dexfenfluramine (September 15, 1997)
* Valvular heart anomalies in patients taking fenphen (July 8, 1997)
* Recall of albumin expanded. (October 3, 1996)

Drug Alerts (see also FDA actions above)

Identification of crystals in kidneys of AIDS patients treated with foscarnet (Sep 1998 AJKD)
Ma-Huang strikes again: Ephedrine nephrolithiasis (Jul 1998 AJKD)
Vascular complications associated with use of HIV protease inhibitors: letters (Jun 1998 LANCET)
Interactions between cyclosporine and newer antidepressant medications (Feb 98 AJKD)
Possible neurologic effects of fentanyl in dialysis patients (Nov 97 ASN abstract)
Amiodarone, a forgotten nephrotoxic? (Nov 97 ASN abstract)
HIV protease inhibitor associated nephritis (Nov 97 ASN abstract)
Lactic acidosis induced by stavudine (d4T) (Nov 97 ASN abstract)
Valvular heart disease associated with fenfluramine-phentermine (Aug 97 NEJM)
Severe hepatitis in patients with AIDS and hemophilia B treated with indinavir (Aug 97 LANCET)
Zafirlukast (Accolate) and Churg Strauss Syndrome (Jul 97 FDA)
Pancreatorenal syndrome associated with combination antiretroviral therapy in HIV infection (Jun 97 LANCET)
Pentoxifylline promotes replication of human cytomegalovirus in vivo and in vitro (May 97 BLOOD)
Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression (May 97 JCI)
Thrombotic thrombocytopenic purpura associated with ticlodipine therapy (Apr 97 JASN)
Acute hypertension as an adverse effect of pyrazinamide (May 97 JAMA)
Brief report. Colchicine toxicity in patients with chronic renal failure (Oct 96 NDT)
Drug-interaction-induced rhabdomyolysis (Sep 96 NDT)
Calcium channel blockade and the incidence of cancer in aged populations (Aug 96 LANCET)
Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs (Aug 96 JAMA)
Calcium antagonists and mortality in patients with coronary artery disease: A cohort study of 11,575 patients (Jul 96 JACC)
Grapefruit juice increases antihypertensive effect of calcium channel blockers (Jul 96 AFM)
Long-term study of calcium antagonists: Reassessment of the Furberg hypothesis. (June 96 ISH abstract)
Amlodipine increases cyclosporine levels in hypertensive renal transplant patients: results of a prospective study (Jun 96 JASN)
Bouncing creatinine levels (Jun 96 NEJM)
Increased incidence of angioedema in blacks treated with ACE- inhibitors (May 96 ASH abstract)
Renal impairment associated with losartan (Apr 96 AIM)
Risk of gastrointestinal hemorrhage with calcium antagonists in hypertensive persons over 67 years old (Apr 96 LANCET)
Near fatal hyponatremic coma due to vasopressin over-secretion after "ecstasy" (3,4-MDMA) (Apr 96 LAN)
Mesalazine associated interstitial nephritis (Apr 96 NDT)
Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis (Mar 96) Ann Intern Med
Rolaids-yogurt syndrome: A 1990s version of milk-alkali syndrome (Feb 96 AJKD)
Hyperkalemia in hospitalized patients treated with trimethoprim- sulfamethoxazole (Feb 96 AIM)
Falsely elevated serum vancomycin concentration in hemodialysis patients (Jan 96) Am J Kidney Dis
Analgesics and the kidney: Summary and recommendations to the Scientific Advisory Board of the NKF from an Ad Hoc Committee of the NKF (Jan 96) Am J Kidney Dis
Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on CAPD (Jan 96) Am J Kidney Dis
Losartan-induced angioedema. December 7, 1995
Clarithromycin may increase digoxin levels by an action on fecal flora. November 30, 1995
Diltiazem-associated cutaneous lupus-like lesions. November 23, 1995
Cisapride (Propulsid®); cardiac arrhythmias when coingesting drugs that inhibit cytrochrome P450. October 14, 1995
Possible increased mortality with short-acting dihydropyridine calcium channel blockers. September 1, 1995 (This is controversial and may not apply to long-acting (slow GI release) forms of these drugs. For a more complete discussion, including the Jan 25, 1996 FDA Advisory Committee recommendations, click here).


Toxin Alerts

Chinese herbs nephropathy or the evils of nature (Sep 1998 AJKD)
End-stage renal disease among silica-exposed gold miners (Apr 97 JAMA)
Outbreaks of Escherichia coli O157:H7 infection and cryptosporidiosis associated with drinking unpasteurized apple cider (Jan 97) MMWR
Acute renal failure in Haitian children due to diethylene glycol adulteration of acetaminophen elixir. June, 1996
Two Vietnamese patients with refractory hypertension from high-salt ethnic food additives. (February, 1996)
Pseudomonas peritonitis from contaminated well-water. (February, 1996)
Severe illness (metabolic acidosis, pH 6.7-6.9) possibly associated with consumption of Kombucha tea. December 8, 1995 (MMWR)
Smoking a major risk factor for albuminuria in type II diabetics. November 3, 1995 (ASN)
Mushroom ingestion (Amanita, Cortinarius, Paxillus); acute renal failure October 13, 1995 (NEPHROL discussion thread)
Raw carp gallbladders; acute renal failure after ingestion of. August 4, 1995 (MMWR)


Device Alerts

Urgent recall: Cobe Centrysystem3 blood tubing sets (outbreaks of hemolysis) (May 98 FDA) See also:
Multistate outbreak of hemolysis in hemodialysis patients - Nebraska and Maryland, 1998 (Jun 98 MMWR)
A dangerous error in the dilution of 25 percent albumin (Apr 1998)
Deaths due to separation of adapter connection to venous dialysis catheters (Mar 1998)

Anaphylaxis to chlorhexidine-impregnated medical devices (Mar 1998)
Outbreaks of Gram negative bacterial bloodstream infections traced to probable contamination of hemodialysis machines. (Jan 98 MMWR)
Vision, hearing loss after use of markedly outdated cellulose acetate dialyzers (Oct 96 CDC)
Hemolysis in membrane plasma separators: is it caused by filter or user? (Sep 96 AO)
Sterile peritonitis outbreaks among peritoneal dialysis patients associated with possibly contaminated commercial dialysate. New York. (Aug 96 NYHD)
The site of injection affects erythropoietin levels during dialysis (Jul 96 ASAIOJ)
Hemolytic reactions mechanically induced by kinked hemodialysis tubing (Feb 96) Am J Kidney Dis
Dialysis machines: venous pressure limits don't stop the pump after inadvertent disconnection. November 3, 1995 (ASN)


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