key Try Dr. Aronoff's BASIC ESRD PHARMACOKINETICS . This quiz deals with issues of dialyzability of drugs, how to give drugs to ESRD patients that are removed by dialysis, with examples of severe side effects from two drugs that can manifest in ESRD patients.
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Aronoff

Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer?
How does epoetin alfa work? What is CERA and how is it different? What are the half-lives of various ESAs and how may this impact therapy and cost? What is Hematide and how does it work? What are prolyl hydroxylase inhibitors and how do they affect anemia? What are initial results with FG-2216? How can ESA dosing be individualized using a neural net approach? (RPA 2006 Satellite Symposium) (more...)

Updated: May 09, 2008 (M09)
M09 Darapladib lowers the activity of inflammatory enzyme associated with vascular plaque.
M05 ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M02 New ACE 2 activator compounds lower blood pressure in rats and also reduce cardiac and renal fibrosis.
A28 FDA approves Relistor (methylnaltrexone) for opioid-induced constipation.
A25 First ever activator of ENAC sodium channel developed.
A24 GAO says that FDA lacks resources to inspect non-US drug suppliers; only 8% are being inspected now.
A23 Genzyme to build new research and development center in Beijing.
A23 Some compounds in Chinese bitter melon identified with activity against diabetes.
A22 CMS releases standards for e-prescribing of drugs.
A21 Massachusetts Senate unanimously passes a law banning all pharma gifts to doctors.
A19 Democrats propose labeling requirements for food and drugs which would list country of origin.
A10 FDA notice regarding investigation of mycophenolate mofetil regarding progressive multifocal leukoencephalopathy.
A07 New antimicrobial proteins identified in alligator blood
A04 AMAG Pharma presents data on new iron supplement at NKF Spring Clinical Meeting.
A03 New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
Industry Advances Emphasis
archive
Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer? (Aronoff) RPA Satellite Symposium 2006
Literature Review: Non-Potassium Fluid-Electrolyte and Acid-Base Disorders (Palmer) ASN Renal Week 2005
The Pathway to Approval of Novel Agents for Renal Diseases (Greene, Throckmorton, Lewis) ASN Renal Week 2005 (audiofiles)
Contrast Induced Nephropathy (CIN): Clinical Significance and Prevention (Palevsky, Tumlin) ASN Renal Week 2005 (audiofiles)
Metals, the Environment, and Miscellaneous Toxins (Batuman, Nortier, Ritz, DeBroe, Lewis, Wolfe) ASN Renal Week 2005 (audiofiles)
Prescribing for Patients with CKD Including Dialysis (Swan, Bennett, DeBroe, D'Haese) ASN Renal Week 2005 (audiofiles)
General Aspects of Nephrotoxicity and Analgesics (Perazella, Markowitz, Clark, DeBroe, Elseviers, Henrich) ASN Renal Week 2005 (audiofiles)
Specific Nephrotoxins (Molitoris, Berns, Palevsky, Shihab, Launay-Vacher, Isnard-Bagnis) ASN Renal Week 2005 (audiofiles)
Statins as Anti-Inflammatory Drugs (Wheeler) RRI 2005 (audiofiles)
New Phosphate Binders (Bargman) ADC 2005 (audiofiles)
Herbs and Heavy Metals: A Recipe for Kidney Failure (Kupin) ASN Board Review 2004

Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
Lessons for Medicare Part D in the hemodialysis community (Nayeem, Chertow) BMC Nephrology 07-06
ESRD PHARMACOKINETICS
Drug Dosing in Renal Failure
(link now works)
HDCN Topic Pages
Interstitial Nephritis
Adverse drug effects
OTHER LINKS
Australian Prescriber
Drug Facts and Comparisons
GSM Clin Pharm
Manufacturer Directory
MedPharm Pharmacology Links
Nephrology Pharm Assoc
Pharmacy Times Links
PowerPak Pharm CE
Renal Pharmacist Network
U.S. Pharmacopoeia

Dr. George Aronoff, M.D.
Professor of Medicine and Pharmacology, University of Louisville School of Medicine, Louisville, KY.