Kawai R, Takagawa K, Hara M, Miyata T, Maeda K, Horiuchi S
Pathohistological demonstration of advanced glycation end products in amyloid tissues of long-term hemodialysis patients
Japanese Soc Nephrol
J Japanese Soc Nephrol (Nov) 37:(suppl)85 1995

In patients on hemodialysis (HD) over 6 years, methylcarboxylysine (CML) and pentosidine (PE), both of which are chemical derivatives of advanced glycation end products (AGEs), were clearly demonstrated in the intervertebral disc amyloid tissues by immunohistological techniques using anti-CML-AGE and anti-PE-AGE antibodies. In contrast, in patients on HD less than 6 years, no CML and no PE were detected, and macrophage migration was not observed in the amyloid tissues. In amyloidosis-related bone cysts, both CML and PE were detected, and bone reabsorption by osteoclasts was observed.

Comment: These pathohistological findings support the hypothesis that amyloid fibrils are modified by AGEs in long-term HD patients. The amyloid fibrils modified by AGEs may induce macrophage migration, with the cytokines secreted by the macrophages causing bone reabsorption. (T. Shinzato)

To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Japanese Soc Nephrol
CRF by organ system : Joint disease, beta-2 microglobulin

---

---