Fukagawa M, Kidaoka M, Fukuda N, Ekil N, Kurokawa K
Direct injection of 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3)
into the parathyroid gland of patients with
hyperparathyroidism refractory to 1,25(OH)2-D3 pulse therapy
Japanese Soc Nephrol
J Japanese Soc Nephrol
(Nov) 37:(suppl)100 1995
In 7 patients suffering from hyperparathyroidism refractory to pulse therapy,
1-microgram/ml of 1,25-(OH)2-vitamin D3 solution, the volume of which was
approximately 70 % of the estimated volume of an enlarged parathyroid gland,
was injected
under ultrasonic guidance, 3 times weekly for 2 weeks. Shortly after
injection therapy, the blood
serum PTH levels fell from 711 +/-213 pg/ml to 255 +/- 138 pg/ml.
During the subsequent 4 weeks, the blood PTH concentration
decreased further, possibly due to continued use of oral 1,25-(OH)2D3
pulse therapy.
(T. Shinzato)
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