Schiffl H, Sitter T, Lang S, Konig A, Held E
Effect of the dialysis membrane on mortality rate in
patients with acute renal failure International Society for Artificial Organs
Artif Organs
(Nov) 11:1037 1995
This seems to be the same data set as published in Lancet last fall. Seventy
six ARF patients were randomized to be dialyzed with cuprophane vs. PAN
membranes using a prospective design. Patient age and APACHE scores were
similar. Mortality rate was substantially higher in the CUP group (66 vs.
37%, p < 0.05) with a higher incidence of lethal sepsis in the CUP group,
esp. due to gram negative bacteria, e.g., Enterobacter.
Comment: This study is in line
with that of Hakim et al in NEJM, who found a strong trend toward decreased
mortality with synthetic membranes in ARF, but is not in agreement with a
paper by Schafer in Artif Organs in
May of 1995. This remains an area of some controversy.
(J. Daugirdas)
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