Ohbayashi T, Shinzato T, Nakai S, Miwa M, Takai I, Maeda K
Higher death rates for diabetics on hemodialysis and for
hemodialysis patients with lower protein catabolic rate are
related to lower creatinine generation rate
International Society for Artificial Organs
Artif Organs
(Nov) 11:1042 1995
The relation between urea generation (as PCRn) and mortality has been
examined by many. In this presentation the importance of creatinine
generation (GCr) is studied as a predictor of mortality in hemodialysis
patients. 2800 patients were studied. GCr was lower in diabetics, and there
was a correlation between GCr and PCr. In a multivariate analysis,
controlling for GCR eliminated most of the increased risk of dying due to
diabetes and low PCR.
Comment: These data are in agreement with Lowrie, who finds the serum
creatinine level to be an extremely important predictor of mortality.
Presumably patiens with increased lean body mass and muscle mass generate
more creatinine, and are healthier with better nutritional status, and thus
live longer.
(J. Daugirdas)
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International Society for Artificial Organs
CRF: Problem Areas :
Outcomes (Morbidity, Mortality)
CRF by organ system :
Nutrition