Nakai S, Miwa M, Kato T, Kobayakawa H, Takai I, Morita H,
Shinzato T, Maeda K
Effectiveness of hemopurification based on convective transport
for reduced grip power in carpal tunnel syndrome
International Society for Artificial Organs
Artif Organs
(Nov) 11:1043 1995
This is an evaluation of the clinical benefits of a new push/pull
hemodiafiltration system invented by the Nagoya group. This system results
in increased large solute removal. 13 patients with severe carpal tunnel
syndrome were treated for 8 weeks using P-P hemodiafiltration using a PAN
membrane. Eight controls were treated with PAN without the P-P
hemodiafiltration option. Hand grip power increased very substantially in
the P-P group and not at all in the conventional group. The authors conclude
that reduced hand grip may be due to accumulation of unknown low molecular
weight proteins, and that P-P hemodiafiltration can help patients with this
problem.
Comment: The push-pull hemodiafiltration is an interesting
innovation. I am skeptical that, in the absence of a double-blind trial
design, one can adequately assess an outcome measure such as handgrip
strength.
(J. Daugirdas)
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International Society for Artificial Organs
CRF by organ system :
Joint disease, beta-2 microglobulin
other extracorporeal therapies :
New dialysis methods, hemodiafiltration