Polenakovic M, Sikole A
Is erythropoietin a survival factor for the red blood
cells
22nd ESAO Congress (Eur Soc Artif Organs)
Int J Artif Organs
(Oct) 18:428 1995
Chromium-51 tagging of erythrocytes was used to assess RBC survival in 18
anemic dialysis patients studied on multiple occasions. Before correction of
anemia (Hct 24%) the RBC half-life averaged 24 days. After 12 months of EPO
therapy, mean Hct was 33% and RBC half-life had increased to 27 days. More
than a year later, after EPO was stopped for non-medical reasons
(?availability), RBC half-life in 15 of the patients had fallen back to a
mean of 22 days.
Comment: I would like to see a population analysis to determine
whether this observation of increased longevity might be a mathematical
consequence of an increased "birth rate", without a true increase in
longevity per se.
(J. Daugirdas)
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22nd ESAO Congress (Eur Soc Artif Organs)
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