Fuchs M, Hampl H, Fischer HCh, Riedel E
Hemodialysis patients with complete correction of renal anemia by
rhEPO: Polyamines
22nd ESAO Congress (Eur Soc Artif Organs)
Int J Artif Organs
(Oct) 18:422 1995
In uremic patients, certain polyamines, notable spermine and spermidine,
inhibit erythropoiesis. When dialysis patients were divided into groups of
10 based on Hct levels, those most anemic were found to have the highest
plasma levels of polyamines. Polyamine levels ranged from 2.28 umol/L in
those with Hgb < 8.5 g/dl to 0.65 in patients with Hgb < 13 g/dl. Control
levels were 0.32.
Spermine was the main polyamine elevated in the plasma, whereas spermidine
was increased in RBCs. To what extent the increased polyamine levels were
the cause of the lower Hgb vs. the effect of anemia was not clear (to this
reviewer).
(J. Daugirdas)
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22nd ESAO Congress (Eur Soc Artif Organs)
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