Pontremoli R, Sofia A, Tirotta A, Ravera M, Nicolella C, et
al.
Microalbuminuria is associated with worse cardiovascular
risk profile and target organ damage in essential
hypertension
Clin Hyp Nephrol (Calab)
(Sep) : 1995
In the screening phase of M.A.G.I.C. (Microalbuminuria: A Genoa Investigation
on
Complications) we have so far examined 894 patients with essential
hypertension
in order to define the prevalence of microalbuminuria and its relationship
with
other cardiovascular risk factors and target organ damage.
The prevalence of microabluminuria was 8.2%. Patients with microalbuminuria
showed higher blood pressure and uric acid levels, lower HDL/LDL cholesterol
as
well as greater prevalence of retinopathy and major ECG changes.
Microalbuminuric patients also had increased carotid wall thickness (0.96+/-
0.02
vs 0.69 +/-0.05 mm, n=32, p= 0.0001) and higher intrarenal vascular
resistances
(mean resistive index 0.62+/-0.01 vs 0.58+/-0.01, n=30, p= 0.012) compared to
a
group of matched normoalbuminuric controls with essential
hypertension.
The results suggest that microalbuminuria in essential hypertension patients
is
associated with an undesirable pattern of cardiovascular risk factors and
with
evidence of target organ damage.
(authors)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
H: Pathophysiology :
Kidney in hypertension