Ribstein J, Du Cailar G, Mimran A
Estrogen replacement therapy improves renal vascular response to L-arginine in menopausal women with essential hypertension
12th Annual ASH Meeting
Am J Hypertens (Apr) 10:12A 1997

The role of nitric oxide (NO) in essential hypertension (EH) is under investigation. The authors have previously shown a blunted renal-vascular response to L-arginine, an NO-precursor, in patients with EH. Gender differences in vascular response, it was hypothesized, may underline the occurrence of vascular disorders and of renal disease.

In the present work the effects of estrogen replacement therapy (ERT) on the renal-vascular response to L-Arginine (30 g iv within 30 min) were tested in a subgroup (n = ?) of 20 women with untreated EH. Results show a modest improvement in ERPF, GFR, and Na excretion rates in women with EH receiving ERT, during L-Arginine infusion. These results suggest that estrogens may influence vasomotor tone via endothelial function and the NO-pathway.

Comment: Long-term effects of ERT on the renal-vascular tone and the NO-pathway and possible improvement in clinical outcomes in EH women remain to be determined. (Armando Lindner, M.D., University of Washington, Seattle)

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12th Annual ASH Meeting
H: Special problems : Women
H: Pathophysiology : Endothelium, Nitric Oxide

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