Masuo K, Mikami H, Ohigara T
Gender differences in insulin sensitivity and sympathetic
responsiveness in young hypertensives
12th Annual ASH Meeting
Am J Hypertens
(Apr) 10:110A 1997
Hypertensives treated with captopril or long-acting nifedipine were compared
for effects
on insulin, glucose and plasma norepinephrine responses during and oral GTT.
After one or
two year's treatment, insulin responses, characterized by AUC, were improved
both by
captopril and nifedipine treatment. AUC for norepinephrine also decreased
with captopril
treatment but increased with nifedipine.
Comment: There are very few studies examining the long-term effects
of either ACEI
or CEB on insulin resistance or sympathetic responsiveness, so the data
presented here are
welcome. They confirm the impression that nifedipine, even in a long-acting
preparation,
may cause neurohumoral activation, which may be undesirable. It is of
interest that the
effects on insulin and norepinephrine seem to be directionally different,
which suggests
that the net impact of nifedipine improves insulin resistance, even though
SNS activity is
intensified. This suggest that the effect of vasodilation, which may improve
glucose and
insulin delivery to skeletal muscle, may be more important than SNS
activation as a
determinant of insulin resistance.
Although the title of the manuscript highlights gender differences, the only
positive finding in this regard was a stronger effec of both ACE inhibitors
and nifedipine on insulin sensitivity in men vs. women.
(Alan Weder, M.D., University of Michigan)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
12th Annual ASH Meeting
H: Special problems :
Women
H: Special problems :
Obesity, Insulin Resistance