Prasad AN, Zabetakis PM
Value of bioelectric impedance analysis in predicting
GFR in hospitalized patients
1996 Spring Clinical Nephrology Meetings
Am J Kidney Dis
(Apr) 26:A12 1996
In this abstract an attempt is made to derive a new alternative to the
Cockroft-Gault formulae for measuring GFR. The authors use a
measurement of fat-free mass based on bioelectric impedance and a
formula they previously derived relating GFR to fat-free mass. They
show, in ten hospitalized patients with mild renal failure, that GFR
derived this way is closer to actual 24-hour creatinine clearance than
is the Cockroft-Gault estimate.
Comment: Strictly speaking, they should be talking about
creatinine clearance and not GFR, as the two are well known to differ,
especially in patients with renal failure. I am also not convinced
that doing bioelectric impedance is more convenient and cost effective
than collecting a 24-hour urine, although results might be more
reproducible. Nevertheless, the technique is very interesting and
would have obvious advantages in people who have trouble doing
reliable urine collections. Peter G. Blake, M.D., Victoria
Hospital, London, Ontario)
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1996 Spring Clinical Nephrology Meetings
Assessing renal function :
Creatinine clearance