Ruiz-Ortega M, Bustos C, Egido J
Angiotensin II triggers monocyte chemoattractant protein-1
MCP-1 transforming growth factor (TGF-B1) and matrix protein
gene expresion in mesangal cells and interstitial renal fibroblast
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A58 1996
Angiotensin II release within the renal microcirculation play a
pivotal role in the pathogenesis of renal damage in different models
of progressive renal diseases. Extracellular matrix expansion and
monocytes infiltration are common histopathological findings in these
models. Ruiz-Ortega et al, in this study, suggest that the renal
deleterious effects of Angiotensin II may be mediated by TGF-b1 and
MCP-1. Indeed, they clearly demonstrate that angiotensin II can
induce, in vitro, MCP-1 and TGF-b1 gene expression in mesangial cells
and interstitial fibroblast, suggesting a new and interesting
mechanism of action for this vasoactive peptide in the pathogenesis of
progressive renal damage. (Loreto Gesualdo, M.D., University of Bari,
Italy)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
33rd Congress of the Eur Dial Transplant Assoc
Proteinuria/Hematuria :
Mechanisms of renal injury