McLaughlin K, Harden P, Boulton-Jones M, Connel JMC, Jardine
A
ACE and angiotensin genotype influence progression of
primary renal disease
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A162 1996
In this study the I/D polymorphism in the gene for Angiotensin Converting
Enzyme (ACE) and the M235T polymorphism in angiotensinogen (AGT) gene was
evaluated in 850 patients with various primary renal diseases. DD
homozygotes for ACE genotype had more rapidly progressive disease as
determined by the slope of serum creatinine against time. Patients with the
AGT 235T allele tended to have higher initial blood pressures and to require
renal replacement therapy earlier.
Comment: These data suggest that increased activity of the
renin-angiotensin system is linked with more rapid progression of all forms
of renal disease. Genetic association studies require very large populations
to provide definitive results. This study provides a convincing basis for
promoting a large scale, international collaborative study (Bruno
Cianciaruso, M.D., University of Naples, Italy).
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33rd Congress of the Eur Dial Transplant Assoc
CRF by problem area :
Progression