Locatelli F, Mastrangelo F, Redaelli B, Ronco C, Marcelli D,
La Greca G, Orlandini G, et al
Randomized trial on the effect of different membranes and
dialysis technologies
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A236 1996
There is circumstantial evidence that biocompatible membranes
attenuate dialysis related intradialytic and long term complications
but the issue has been scarcely investigated in prospective ,
randomized, clinical trials.
The primary aim of this study
involving 71 dialysis units and 380 patients is that of comparing
high flux and low flux polysulphone with cuprophan in terms of
treatment tolerance, nutritional parameters and beta2 microglobulin
levels. To date the average observation period is 24 months. No
statistical difference has until now emerged between polysulphone
membranes (high and low flux) and cuprophan as for treatment tolerance
and nutritional parameters. Beta2 microglobulin was significantly
lower (-25%) in patients on high flux polysulphone than in those on
low flux polysulphone or cuprophan.
Comment: Thus,
the interim analysis of this study show that the use of polysulphone
do not produce any measurable clinical benefit in comparison with
cuprophan in a 2 years follow-up. However, the clinical impact of
lowering beta2 microglobulin plasma concentration in patients on high
flux polysulphone may require a longer observation period to fully
emerge (Carmine Zoccali, M.D., Reggio Calabria, Italy).
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33rd Congress of the Eur Dial Transplant Assoc
Basic hemodialysis :
Dialyzers
CRF by organ system :
Nutrition