Johnston PA, Davison AM
Actuarial survival and associated malignancy in
membranous nephropathy: a registry linkage study
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A101 1996
The risk of cardiovascular disease and malignancy is considered to be high
in patients with membranous nephropathy.
328 patients with membranous nephropathy included in the MRC
Glomerulonephritis Registry were re-traced in the computerized British
National Health Service Registry. The age of these patients was 51 years and
the actuarial survival was 82% at 10 years and 68% at 15 years post biopsy.
Thirty% of deaths were attributable to cardiovascular causes. malignancy was
reported in 28 cases (8.5%). This figure is much higher than in age and sex
matched individuals of the British population (1.1%). Patients with
malignancy were older at the time of biopsy (62 years). In 10 cases (36%)
the malignancy was recorded as present at the time of biopsy.
Comment:
In this large cohort of patients with membranous nephropathy there was a 82%
survival at 10 years post-biopsy and a high rate of cancer (Carmine
Zoccali, M.D., Reggio Calabria, Italy).
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33rd Congress of the Eur Dial Transplant Assoc
Proteinuria/Hematuria :
Membranous GN
Nephrotic Syndrome :
Treatment (CEI, indomethacin, lipid drugs)