Hand MF, Haynes WG, Anderton JL, Webb DJ
Endothelin-1 generation and endothelin-1 mediated basal
vascular tone is decreased in chronic renal failure
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A65 1996
Patients with chronic renal failure have high plasma endothelin-1
(ET-1) concentration but it remains uncertain whether increased this
alteration has important cardiovascular consequences in these
patients.
The authors investigated the role of ET-1 in the
maintenance of basal vascular tone in 8 patients with stable CRF and
in 8 healthy subjects. Infusion of Et-1 in the radial artery produced
the same decrease in forearm blood flow in CRF and in healthy
subjects. However, inhibition of ET-A receptor (by BQ 123) caused an
attenuated increase (+11%) in forearm blood flow in CRF patients in
comparison with healthy subjects (+44%). On the other hand, the
increase in forearm blood flow elicited by the inhibition of ET-1
converting enzyme (by phospharamidon) was markedly reduced in CRF
patients (+60% vs +176%).
Comment: This study shows
that the contribution of ET-1 to the maintenance of basal vascular
tone is reduced in CRF and that the vascular generation of ET-1 is
blunted in these patients (Carmine Zoccali, M.D., Reggio Calabria,
Italy).
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33rd Congress of the Eur Dial Transplant Assoc
CRF by organ system :
Cardiovascular/Hypertension