Grandaliano G, Ranieri E, Monno R, Montinaro V, Gesualdo L,
Schena FP
Monocyte chemotactic peptide-1 (MCP-1) expression in IgA
nephropathy: a pathogenetic role in interstitital monocytes
recruitment
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A25a 1996
Tubulointerstitial changes, even in glomerulonephritis, are the best
indicators of renal outcome. Monocytes infiltrating the interstitium
play a key role in the pathogenesis of tubulointerstitial lesions.
Grandaliano et al investigated the pathogenetic involvement of MCP-1
in the interstitial monocyte infiltration observed in IgAN.
They show an increased MCP-1 expression at the tubulointerstitial
level in this disease, strictly correlated with the extent of monocyte
infiltrate. Indeed, monocytes were localized exclusively around the
structures expressing MCP-1, clearly suggesting a role for this
chemokine in modulating their influx into the interstitial space.
Moreover, the observation of an increased MCP-1 urine excretion
correlated to its tissue expression suggests the urine level as a
reliable marker of disease activity. (Loreto Gesualdo, M.D.,
Altamura, Italy)
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33rd Congress of the Eur Dial Transplant Assoc
Proteinuria/Hematuria :
Mechanisms of renal injury
Proteinuria/Hematuria :
IgA Nephropathy