Geiger H, Mai M, Fierlbeck W
The role of chemokines and cytokines in the initiation and
progression of hypertensive nephrosclerosis
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A52 1996
This study is a fresh look into the mechanisms that underlie early
tubular cell proliferation, mononuclear cell recruitment, and
deposition of matrix proteins within the renal interstitium in
hypertension.
Two-kidney one-clip hypertensive rats were
used and cortical expression of the chemokines MCP-1 and RANTES and of
the cytokines TGF-1 mRNA and PDGF-B mRNA were examined in the non
clipped kidneys of hypertensive rats as well in kidneys of sham
operated rats. TGF-1 mRNA was raised in the prehypertensive as well
as in the hypertensive phase while MCP-1 mRNA and PDGF-B mRNA were
raised only in the hypertensive phase. MCP-1 and PDGF B correlated
with monuclear interstitial infiltration and with tubular
proliferation.
Comment: This stimulating study would have been even
more interesting had it given information also in the clipped
kidney. The clipped kidney is indeed exposed to angiotensin but not
to hypertension (Bruno Cianciaruso, M.D., University of Naples,
Italy).
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33rd Congress of the Eur Dial Transplant Assoc
H: Pathophysiology :
Kidney in hypertension