Aprile C, Villa G, Saponaro R, Piazza V, Suppi A, Yurisic D,
Buonocore M, Marinone MG, et al
A new approach to the detection of dialysis related
amyloidosis with 99m Tc aprotinin
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A235 1996
Imaging of amyloidosis in dialysis patients is rarely performed
because radiotracers are costly and difficult to obtain. The
authors have explored the potential of Tc-Aprotinin , a low cost
and easily available tracer, in localizing amyloid deposits in
25 HD patients.
Significant accumulation in medium and
large size joints was observed in 19 HD patients. In contrast, no
accumulation was found in 8 non-uremic patients with
osteoarthropathy. The uptake intensity as well as the number of
joints visualized was directly related with the duration of HD
treatment and with subjective pain score and functional impairment.
Interestingly in three patients there was accumulation in the lung
and in the thyroid. Furthermore all anephric patients exhibited
accumulation of the radiotracer in the gastrointestinal system.
Comment: This pilot study suggests that Tc-Aprotinin
is a promising tracer for dialysis amylodosis. The value of this
radiotracer needs now to be formally assessed in a larger number
of patients by using rock solid evidence of dialysis amyloidosis
(histology) (Carmine Zoccali, M.D., Reggio Calabria, Italy).
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33rd Congress of the Eur Dial Transplant Assoc
CRF by organ system :
Joint disease, beta-2 microglobulin