Amore A, Cirina P, Semeraro A, Iavarone A, Gianoglio B,
Fiorucci GC, Coppo R
Proteinuria induces apoptosis in cultured tubular cells
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A135 1996
This paper tests the hypothesis that filtered albumin induces apoptosis of
tubular cells and that this mechanism participates in the pathogenesis of
interstitial damage in nephrotic syndrome. Apoptosis was evaluated in human
proximal tubular cells incubated for 12 hours with human albumin at three
different concentrations (a: physiological tubular concentration; b:
concentration similar to that seen in massive proteinuria; c: serum
concentration). DNA fragmentation occurred only with very high albumin
concentrations (( massive proteinuria).
Comment:
Apoptosis may have a significant role in the pathogenesis of renal damage
in very severe nephrotic syndrome (Bruno Cianciaruso, M.D., University of
Naples, Italy).
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33rd Congress of the Eur Dial Transplant Assoc
Nephrotic Syndrome :
Pathogenesis, complications, RVT