Aguilera A, Codoceo R, Selgas R, Jimenez C, Bajo MA, Sanchez
C, Cubas A, Possante C, Dealvaro F
Intestinal absorptive function and plasma levels of
anorexigenic substances in peritoneal dialysis patients. Their
relationship with malnutrition
33rd Congress of the Eur Dial Transplant Assoc
Nephrol Dial Transplant
(Jun) 11:A244 1996
This study explores the relationship between gastrointestinal tract
function and nutrition. Several GI peptides (gastrin,
cholecystokinin, gastrin-regulation peptide, GIP, pepsinogen I-II) and
TNF-a (which has an anorexant effect) were measured in 36 stable
patients on peritoneal dialysis.
A protein loss enteropathy
was present in 11 % of patients (defined on the basis of alpha-1
antitrypsin fecal clearance) and these patients showed significantly
reduced serum albumin in comparison with those without enteropathy.
Plasma levels of cholecystokinin and TNF-a were elevated in the
majority of patients. Interestingly cholecystokinin was directly
related with biochemical nutritional parameters (albumin, NPCR). On
the other hand TNF-a was inversely related with the same
parameters.
Comment: These data need confirmation in
a larger study. It remains unclear whether these findings are
peculiar to patients on peritoneal dialysis (Bruno Cianciaruso,
M.D., University of Naples, Italy).
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33rd Congress of the Eur Dial Transplant Assoc
CRF by organ system :
GI/Liver, Hepatitis
CRF by organ system :
Nutrition