Li P, Chappell MC, Ferrario CM, Brosnihan KB
Angiotensin (1-7) potentiates vasodilation of
bradykinin in canine coronary artery by local release of
nitric oxide
50th Annual Fall Conference AHA Council for High Blood Pressure
Research
Hypertens
(Sep) 28:523 1996
Angiotensin 1-7 (Ang 1-7, derived from Ang I) has been shown to potentiate
the hypotensive effect of bradykinin (BK) in vivo. These studies, in
endothelium-intact, isometrically contracted canine coronary artery rings,
demonstrated that Ang 1-7 potentiated BK-induced relaxation, but not that
due to either acetylcholine or nitroprusside (an NO donor). This
potentiation was ablated by nitroarginine (an NO synthase inhibitor) but not
by KCl (used to inhibit K-channel-dependent hyperpolarizing factors).
Authors speculate that Ang 1-7 may act locally to augment the BK-dependent
contributions to antihypertensive effects of converting enzyme inhibition.
Comment: This study further describes an interaction in isolated
vessels between Ang
between 1-7 and BK/ Both increased after converting enzyme inhibition and
apparently
are capable of contributing to the antihypertensive effect. While NO appears
to
contribute to this interaction, further experiments using other isolated
vascular preparations and pharmacologic probes will be required to elucidate
this potentially important mechanism.
Jason G. Umans, M.D., University of Chicago
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50th Annual Fall Conference AHA Council for High Blood Pressure
Research
H: Pathophysiology :
Hormonal aberrations