Ferrario CM, Nartell N, Pnillas C, Yunis C, Bridget K, et al
Essential hypertension is associated with low urinary levels of
angiotensin (1-7)
50th Annual Fall Conference AHA Council for High Blood Pressure
Research
Hypertens
(Sep) 28:515 1996
Ferrario and colleagues have previously demonstrated that a metabolite
of agiotensin, Ang-(1-7) promotes natriuresis and diuresis in rats.
Ang-(1-7) is found in high concentrations in rat urine, and the
authors have proposed that urinary excretion is a potential index of
intrarenal angiotensin production. They have now extended their
observations into humans where they demonstrate that essential
hypertensives have significantly lower urinary concentrations and
excretion rates of Ang-(1-7) compared to normotensives. In addition,
they noted an inverse correlation between urinary Ang-(1-7)
concentrations and blood pressure. The correlation suggests the
possibility that a diminished depressor action for Ang- (1-7) could
contribute to hypertension.
Comment: Ang-(1-7) is a metabolite of Ang I and II, and
is found in brain (where it may have biological activity relating to
sympathetic outflow and baroceptor responses), blood and urine.
Earlier studies suggest that ang-(1-7) can increase prostaglandin
production in some tissues, and increased prostaglandin production in
kidneys could contribute to a natriuretic effect. Alternatively,
Ang-(1-7) also can inhibit aldosterone production, which could
promote natriuresis. The effects of anthipertensive drugs and
nonpharmacological interventions may provide further insight into the
role, if any, of Ang-(1-7) in human hypertension.
(Alan Weder, M.D., University of Michigan)
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50th Annual Fall Conference AHA Council for High Blood Pressure
Research
H: Pathophysiology :
Hormonal aberrations