Busjahn A, Knoblauch H, Schuster H, Menz M, Faulhaber H-D,
Luft FC
Angiotensin converting enzyme gene polymorphisms, plasma
levels, and left ventricular size in twins
50th Annual Fall Conference AHA Council for High Blood Pressure
Research
Hypertens
(Sep) 28:544 1996
Insertion/deletion polymorphism of the ACE gene has been
intensively investigated as a marker for cardiovascular
complications, with the DD genotype associated with higher serum
ACE levels and complications. 134 pairs of monozygotic (MZ) (91)
and dizygotic (DZ) (43) normotensive twins were investigated.
When grouped by genotype, age and blood pressures were similar
among the three groups. Serum ACE levels were 57 +/- 25 units in
DD, 43 +/- 18 in ID, and 24 +/- 11 in II (p < 0.01). ACE was
positively correlated with left ventricular mass and posterior
wall thickness (p < 0.05).
Comment: These data indicate that the ACE
locus determines ACE levels and that left ventricular size is
determined by the D allele.
(David J. Leehey, M.D., Loyola University at Chicago)
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50th Annual Fall Conference AHA Council for High Blood Pressure
Research
H: Pathophysiology :
Genetics
H: Drug therapy :
ACE inhibitors