Bloem LJ, Foroud T, Ambrosius W, Tewksbury DA, Pratt JH
Association of angiotensin gene haplotype to the serum
angiotensinogen concentration and blood pressure in blacks and
whites
50th Annual Fall Conference AHA Council for High Blood Pressure
Research
Hypertens
(Sep) 28:545 1996
The T235 variant of the angiotensinogen gene (AGT) has been
associated with higher serum angiotensinogen levels and possibly
hypertension and has been proposed as a genetic predisposing
factor to hypertension in blacks. However, the frequency of T235
in blacks (approx. 80% of the population) makes interpretation of
data difficult. A haplotype consisting of T235 and a G to T
transversion at nt -1074 (T/-1074) was found to correlate with
both serum angiotensinogen and BP in whites as well as blacks.
Comment: Stated differently, a subset of carriers of the T235 allele
have
higher levels of both angiotensinogen and BP. The AGT may play a
role in BP control in both whites and blacks.
(David J. Leehey, M.D., Loyola University at Chicago)
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50th Annual Fall Conference AHA Council for High Blood Pressure
Research
H: Pathophysiology :
Genetics
H: Special problems :
Ethnic populations